Excerpts from from a year end letter from an Australian specialist in drug treatment

Dear friends, neighbours and colleagues,

…It has been a challenging year but with many rewards as we watch our patients achieve their goals, major and minor.  As I approach retiring age I can provide more customised treatment for those with opiate, benzodiazepine and alcohol problems.  Specifically we use split doses, high doses, low doses, frequent swaps between methadone and buprenorphine along with adjuvant therapy using anti-depressants, mood stabilisers, disulfiram, fluvoxamine, propranalol and propantheline.  Yet we are frustrated on a daily basis by the use of ‘crystal’ methamphetamine.  Previously stable, pleasant methadone maintenance patients have become unpredictable and unreasonable.  There have been frequent admissions to psychiatric wards where nothing much can be done after assessment and possibly antipsychotic medication.  We have tried prescribing dexamphetamine for some consenting trial cases but without success at eliminating the use of ‘ice’ (methamphetamine), even for short periods.  We await a positive strategy, perhaps from one of the younger members of the addiction Chapter (RACP).

We continue to address the widespread use of benzodiazepine tranquillizers in our patient population (18-50% dependency among OTP patients according to AATOD).  We have started performing differential urine toxicology which can determine the diazepam-temazepam-oxazepam group from the more potent and dangerous alprazolam, clonazepam and flunitrazepam preparations.  We supervise detoxifying doses in new or unstable patients with some receiving ‘staged supply’ dispensing of diazepam for limited periods for anxiety and/or dependency using either 2mg or 5mg tablets.  The supply of diazepam is contingent on the usual stability criteria for take-home doses of methadone or buprenorphine (sober presentation, housing, vocation, family, finances, attendance, psychiatric, toxicology, etc).  ‘Doctor shopper’ information is now available on line.  More will be said on these matters following a seminar at Sydney University (RPAH) in November by Prof Starcevic, Prof Haber and a brief appearance by myself, chaired by Dr Richard Hallinan of our practice.

We have also had numerous patients leave opiate maintenance successfully in the past 12 months with many others achieving vocational, family and other goals, far from uncontrolled illicit drug or alcohol use.  A fork-lift licence, university degree, new baby, paid off debts, smoking cessation and new housing can all be life changing benefits for those involved.   For others such goals are still at some distance.

The new oral treatments for hepatitis C have allowed us to almost eradicate the disease from our patient group after sometimes frustrating times with interferon-based treatments in the past.  This has been enormously gratifying for patients, their families and our staff as a very positive outcome.  Congratulations are due to Dr Hallinan for most of this important public health work which is subject of continuing publications.

My niece Gracie Hay has spent a couple of sessions in the practice after completing her psychology honours year at Macquarie University.  She has published a fascinating paper on her work with Professor Cornish using cannabinoids to diminish behavioural symptoms of withdrawal and relapse in amphetamine-primed rats (see citation below).  Gracie is now a medical student at Notre Dame University and has some busy years ahead of her.

Merry Christmas and Happy New Year to all from the Byrne Surgery staff, hoping 2019 is a good one for all.

Andrew Byrne ..

https://www.researchgate.net/publication/327938519_Cannabidiol_treatment_reduces_the_motivation_to_self-administer_methamphetamine_and_methamphetamine-primed_relapse_in_rats

Clinic web page: http://methadone-research.blogspot.com/

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Updated: December 22, 2018 — 9:51 am
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